中药大生命科学与技术学院导师：程晓东 正文

　　程晓东，现任中国药科大学生命科学与技术学院长江学者讲座教授、美国德州大学终身正教授，博士生导师。1985年毕业于北京大学生物系，1988年获中科院上海生物化学研究所硕士学位，1994年获美国德州大学博士学位。1995年至1999年，在美国加州大学圣地亚哥分校美国科学院院士Susan Taylor教授实验室从事博士后研究。1999年起在美国德州大学任教，主要从事肿瘤细胞信号转导过程和机制以及原癌基因调控等方面研究。

　　2001年后发表的论文：
　　1. Cheng, X., Phelps, C., and Taylor, S. S. Differential Binding of cAMP-dependent Protein Kinase Regulatory Subunit Isoforms I and II to the Catalytic Subunit. J. Biol. Chem. 276: 4102-4108, 2001.
　　2. Mei, F., Qiao, J., Tsygankova, O. M., Meikoth, J. L., Quilliam, L. A., and Cheng, X. Differential Signaling of cAMP: Opposing effect of Epac and PKA on PKB Phosphorylation and Activation. J. Biol. Chem., 277: 11497-11504, 2002.
　　3. Qiao, J., Mei, F., Popov, V. L., Vergare, L. A., and Cheng, X. Cell Cycle Dependent Subcellular Localization of Exchange Factor Directly Activated by cAMP. J. Biol. Chem., 277: 26581-26586, 2002.
　　4. Jabbur, J. R., Tabor, A. D., Cheng, X., Wang, H., Uesugi, M., Lozano, G., and Zhang, W. Phosphorylation at Threonine 18 of p53 Alters Hydrogen Bonding Attenuating mdm2 Binding and TAFII31 Recruitment. Oncogene, 21:7100-7113, 2002.
　　5. Li, J., Cheng, X., and Lee, J. C. Structural and dynamics of the modular halves of Escherichia coli cyclic AMP receptor protein. Biochemistry, 41:14771-14778, 2002.
　　6. Yu, S., Mei, F., Lee, J. C., and Cheng, X. Probing cAMP-dependent protein kinase holoenzyme complexes by TF-IR and chemical protein footprinting. Biochemistry, 43:1908-1920, 2004.
　　7. Young, T. W., Mei, F., Yang, G., Thomspon-Lanza, J. A., Liu, J., and Cheng, X. Activation of anti-oxidant pathways in Ras-mediated transformation of human ovarian epithelia cell revealed by functional proteomics and mass spectrometry. Cancer Research, 64:4577-4584, 2004.
　　8. Dipilato, L., Cheng, X., and Zhang, J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc. Acad. Natl. Sci. USA., 101:16513-16518, 2004.
　　9. Zhang, L., Cui, R., Cheng, X., and Du, J. Anti-apoptotic effect of serum and glucocorticoid-induced protein kinase is mediated by a novel mechanism activating I B Kinase. Cancer Research, 65:457-464, 2005.
　　10. Cheng, X. Understand signal transduction through functional proteomics. Expert Review in Proteomics, 2:103-116, 2005.
　　11. Young, T. W., Mei, F., Liu, J., Bast, R. C., Jr., Kurosky, A., and Cheng, X. Proteomic Analysis of H-Ras-mediated oncogenic transformation in a genetically defined human ovarian cancer model. Oncogene, 24:6174-6184, 2005.
　　12. Mei, F. and Cheng, X. Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton. Molecular BioSystems, 1:325-331, 2005.
　　13. Mei, F. Young, T. W., and Cheng, X. RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells. FASEB J., 20:497-499, 2006.
　　14. Brobey, R. K. Mei, F. C., Cheng, X., and Soong L. Comparative two-dimensional gel electrophoresis maps for promastigotes of Leishmania amazonensis and Leishmania major. Braz. J. Infect. Dis., 10:1-6, 2006.
　　15. Yu, S., Fan, F., Mei, F., and Cheng, X. Investigating the mechanism of exchange protein directly activated by cAMP activation by FT-IR and structural modeling. Biochemistry. 45:15318-15326, 2006.
　　16. Li, J., O’Conner, K. L., Cheng, X., Mei, F. C., Uchida, T., Townsend, C. M., and Evers, B. M. Cyclic AMP-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and PKA signaling pathways. Molecular Endocrinology. 21:159-171, 2007.
　　17. Young, T. W., Mei, F. C., Rosen, D. G., Yang, G., Li, N., Liu, J., and Cheng, X. Up-regulation of Tumor Susceptibility Gene 101 Protein in Human Epithelial Ovarian Cancer Revealed by functional proteomics. Molecular and Cellular Proteomics. 6:294-304, 2007.
　　18. Ji, Z., Mei, F. C., Xie. J. and Cheng, X. Oncogenic KRAS suppresses GLI1 degradation and activates hedgehog signaling pathway in pancreatic cancer cells. J. Biol. Chem. 282:14048-14055, 2007.
　　19. Young, T. W., Rosen, D. G., Mei, F., Li, N., Liu, J., and Cheng, X. Up-regulation of Tumor Susceptibility Gene 101 Conveys poor Prognosis through Suppression of p21 Expression in Ovarian Cancer. Clinical Cancer Research. 13:3848-3854, 2007.
　　20. Wayne, C. W., Fan, H. Y., Cheng, X., and Richards, J. S. FSH induces multiple signaling cascades: evidence that activation RAS, SRC and the EGF receptor are critical for granulosa cell differentiation. Molecular Endocrinology. 21:1940-1957, 2007.
　　21. Cheng, X., Young, T. W., and Mei, F. C. Proteomics analyses of ovarian cancer using genetically defined human ovarian cancer models. Frontiers in Bioscience. 12:5166-5176, 2007.
　　22. Brock, M., Fan, F., Mei, F., Li, S., Gessner, C., Woods Jr., V. L., and Cheng, X. Conformational analysis of Epac activation revealed using amide hydrogen/deuterium exchange mass spectrometry (DXMS). J. Biol. Chem. 282:32256-32263, 2007.
　　23. Ji, Z., Mei, F. C., Johnson, B. H., Thompson, E. B., and Cheng, X. PKA, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells. J. Biol. Chem.282:37370-37377, 2007.
　　24. Cheng, X. Silent assassin: Oncogenic Ras directs epigenetic inactivation of target genes. Science Signaling. 1:pe14, 2008.
　　25. Ji, Z., Mei, F. C., Miller, A. L., Thompson, E. B., and Cheng, X. Protein kinase A (PKA) isoform RIIβ mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells. J. Biol. Chem. 283:21920-21925, 2008.
　　26. Cheng, X., Ji, Z., Tsalkova, T., and Mei, F. C. Epac and PKA: a tale of two intracellular cAMP receptors. Acta Biochimica et Biophysica Sinica. 40:651-662, 2008.
　　27. Ji, Z., Mei, F. C., Lory, P. L., Gilbertson, S. R., Chen, Y., and Cheng, X. Chemical genetic screening of KRAS-based synthetic lethal inhibitors for pancreatic cancer. Frontiers in Bioscience. 14:2904-2910, 2009.
　　28. Tsalkova, T., Blumenthal D. R., Mei, F. C., and Cheng, X. Mechanism of Epac activation: Structural and functional analyses of Epac2 hinge mutants with Constitutive and reduced activities. J. Biol. Chem. 284:23644-23651, 2009.
　　29. Ji, Z., Mei, F. C., and Cheng, X. Epac, not PKA catalytic subunit, is required for 3T3-L1 preadipocyte differentiation. Frontiers in Bioscience (Elite Ed). 2:392-398, 2010.

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