山东大学生命科学学院导师：盛多红 正文

　　盛多红，博士，山东大学微生物技术国家
　　重点实验室研究人员。
　　
　　联系方式：
　　地址：山东济南山大南路27号，250100
　　电话：13658612032
　　邮箱：dhsheng@sdu.edu.cn
　　
　　学习工作简历：
　　1991．9-1995．7 山东大学微生物学 本科
　　1995．9-1998．7 中科院武汉病毒所微生物学 硕研
　　1998．7-2002．3 山东省科学院和Medgenn公司 科研人员
　　2002．3-2005．3 浙江大学生物物理学 博研
　　2005．7-至今 山东大学生命科学学院讲师、副教授
　　
　　研究方向：围绕微生物生理代谢过程，研究DNA重组修复机制，分析其在细菌耐药性发生中的作用。

　　已发表DNA修复相关论文：
　　Wang L, Sheng D, Han W, Huang B, Zhu S, Ni J, Li J, Shen Y. Sulfolobus tokodaii RadA paralog, stRadC2, is involved in DNA recombination by interacting with RadA and Hjc. Sci China C Life Sci. 2012.（并列第一）
　　Hong Y, Chu M, Li Y, Ni J, Sheng D, Hou G, She Q, Shen Y. Dissection of the functional domains of an archaeal Holliday junction helicase. DNA Repair (Amst). 2012, 11(2):102-111.
　　Wei T, Zhang S, Hou L, Ni J, Sheng D, Shen Y. The carboxyl terminal of the archaeal nuclease NurA is involved in the interaction with single-stranded DNA-binding protein and dimer formation. Extremophiles. 2011, 15(2):227-234.
　　Ma X, Hong Y, Han W, Sheng D, Ni J, Hou G, Shen Y. Single-stranded DNA binding activity of XPBI, but not XPBII, from Sulfolobus tokodaii causes double-stranded DNA melting. Extremophiles 2011, 15(1):67-76.
　　Sheng D, Li M, Jiao J, Sheng X, Deng W, Hua Y. Repression of recA induction by RecX is independent of the RecA protein in Deinococcus radiodurans. J Bacteriol. 2010, 192(13):3540-4.
　　Wu L, Liu B, Hong Y, Sheng D, Shen Y, Ni J. Residue Tyr224 is critical for the thermostability of Geobacillus sp. RD-2 lipase. Biotechnol Lett. 2010, 32(1):107-12.
　　Sheng D, Jao J, Li M, Xu P, Zhang J. RecX is involved in the switch between DNA damage response and normal metabolism in D. radiodurans. J Biochem. 2009, 146(3):337-42.
　　Sheng D, Li M, Jiao J, Ni J, Shen Y. Co-expression with RadA and the characterization of stRad55B, a RadA paralog from the hyperthermophilic crenarchaea Sulfolobus tokodaii. Sci China C Life Sci. 2008, 51(1):60-5.
　　Sheng D, Zhu S, Wei T, Ni J, Shen Y. The in vitro activity of a Rad55 homologue from Sulfolobus tokodaii, a candidate mediator in RadA-catalyzed homologous recombination. Extremophiles 2008, 12(1):147-57.
　　Sheng D, Zhu S, Li M, Jiao J, Ni J, Shen Y. Cloning, expression and radiation inducibility of RadA from the hyperthermophilic archaeon Sulfolobus tokodaii. Wei Sheng Wu Xue Bao 2008, 48(3):317-22.
　　Lu S, Li Z, Wang Z, Ma X, Sheng D, Ni J, Shen Y. Spatial subunit distribution and in vitro functions of the novel trimeric PCNA complex from Sulfolobus tokodaii. Biochem Biophys Res Commun. 2008, 376(2):369-74.
　　Li Z, Lu S, Hou G, Ma X, Sheng D, Ni J, Shen Y. Hjm/Hel308A DNA helicase from Sulfolobus tokodaii promotes replication fork regression and interacts with Hjc endonuclease in vitro. J Bacteriol. 2008, 190(8):3006-17.
　　Zhang S, Wei T, Hou G, Zhang C, Liang P, Ni J, Sheng D, Shen Y. Archaeal DNA helicase HerA interacts with Mre11 homologue and unwinds blunt-ended double-stranded DNA and recombination intermediates. DNA Repair (Amst) 2008, 7(3):380-91.
　　Wei T, Zhang S, Zhu S, Sheng D, Ni J, Shen Y. Physical and functional interaction between archaeal single-stranded DNA-binding protein and the 5'-3' nuclease NurA. Biochem Biophys Res Commun. 2008, 367(3):523-9.
　　Liu B, Hong Y, Wu L, Li Z, Ni J, Sheng D, Shen Y. A unique highly thermostable 2-phosphoglycerate forming glycerate kinase from the hyperthermophilic archaeon P. horikoshii: gene cloning, expression and characterization. Extremophiles 2007, (5):733-9.
　　Liu B, Li Z, Hong Y, Ni J, Sheng D, Shen Y. Cloning, expression and characterization of a thermostable exo-beta-D-glucosaminidase from the hyperthermophilic archaeon Pyrococcus horikoshii. Biotechnol Lett. 2006, 28(20):1655-60.
　　Tian B, Zhang SW, Xu ZJ, Sheng DH, Hua YJ. Effects of PprI and RecX on antioxidant activity of Deinococcus radiodurans. Wei Sheng Wu Xue Bao 2006, 46(2):238-42.
　　Sheng D, Liu R, Xu Z, Singh P, Shen B, Hua Y. Dual negative regulatory mechanisms of RecX on RecA functions in radiation resistance, DNA recombination and consequent genome instability in Deinococcus radiodurans.DNA Repair (Amst) 2005, 4(6):671-8.
　　Sheng D, Gao G, Tian B, Xu Z, Zheng Z, Hua Y. RecX is involved in antioxidant mechanisms of the radioresistant bacterium Deinococcus radiodurans. FEMS Microbiol Lett. 2005, 244(2):251-7.
　　Sheng D, Zheng Z, Tian B, Shen B, Hua Y. LexA analog (dra0074) is a regulatory protein that is irrelevant to recA induction. J Biochem. 2004, 136(6):787-93.
　　Zhang C, Wei J, Zheng Z, Ying N, Sheng D, Hua Y. Proteomic analysis of Deinococcus radiodurans recovering from gamma-irradiation. Proteomics 2004, 5(1):138-143
　　Tian B, Wu Y, Sheng D, Zheng Z, Gao G, Hua Y. Chemiluminescence assay for reactive oxygen species scavenging activities and inhibition on oxidative damage of DNA in Deinococcus radiodurans. Luminescence 2004, 19(2):78-84
　　Gao G, Tian B, Liu L, Sheng D, Shen B, Hua Y. Expression of Deinococcus radiodurans PprI enhances the radioresistance of Escherichia coli. DNA Repair (Amst) 2003, 2(12):1419-27.

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