大连理工大学导师：刘文黎

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大连理工大学水利工程学院导师：安海艳大连理工大学结构工程专业导师孔宇航介绍大连理工大学结构工程专业导师唐建介绍大连理工大学结构工程专业导师齐康介绍大连理工大学物理化学研究生导师梁长海介绍大连理工大学化学工程研究生导师张宁介绍 95%的同学还阅读了： [2022大连理工大学研究生招生目录] [大连理工大学研究生分数线[2013-2021]] [大连理工大学王牌专业排名] [大连理工大学考研难吗] [大连理工大学研究生院] [大连理工大学考研群] [大连理工大学研究生学费] 大连理工大学保研夏令营大连理工大学考研调剂2022最新信息 [大连理工大学研究生辅导] [考研国家线[2006-2021]] [2022年考研时间：报名日期和考试时间]

大连理工大学导师：刘文黎正文

[导师姓名]
刘文黎

[所属院校]
大连理工大学

[基本信息]
导师姓名：刘文黎
性别：男
人气指数：910
所属院校：大连理工大学
所属院系：
职称：馆员
导师类型：硕导
招生专业：

[通讯方式]
电子邮件：wenli@dlut.edu.cn

[个人简述]
在研项目：
1.国家自然科学基金青年项目（主持人）：利用小分子p53-BH3功能模拟物研究Bcl-2-like/p53二聚体调控内源凋亡的分子机制，2016-2018
2.辽宁省博士启动基金（主持人），2016-2018
3.校际合作项目（主持人）：具有生物正交反应标记的糖基供体化学合成，2016-2017
发表论文：
1.LiuY,RenY,CaoY,etal.DiscoveryofaLowToxicityO-GlcNAcTransferase(OGT)InhibitorbyStructure-basedVirtualScreeningofNaturalProducts[J].ScientificReports,2017,7.
2.LiuY,HuangH,LiuM,etal.MicroRNA-24-1suppressesmousehepatomacellinvasionandmetastasisviadirectlytargetingO-GlcNActransferase[J].Biomedicine&Pharmacotherapy,2017,91:731-738.
3.LiuY,HuangH,CaoY,etal.SuppressionofOGTbymicroRNA24reducesFOXA1stabilityandpreventsbreastcancercellsinvasion[J].BiochemicalandBiophysicalResearchCommunications,2017,487(3):755-762.
4.YuboLiu,ZhichaoZhang,TingSong,FurongLiang,MingzhouXie,HongkunSheng.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.BritishJournalofPharmacology,169,1612-1623.
5.YuboLiu,ZhiqiangLi,TingSong,ZuguangXue,ZhichaoZhang.(2013)MechanismsofAnti-leukemicActivityoftheBcl-2HomologyDomain-3MimeticS1.Biomedicine&Pharmacotherapy,67,451-556.
6.YuboLiu，MingzhouXie，TingSong，HongkunSheng,XiaoyanYu,ZhichaoZhang.(2015)AnovelBH3mimeticefficientlyinducesapoptosisinmelanomacellsthroughdirectbindingtoanti-apoptoticBcl-2familyproteins，includingphosphorylatedMcl-1.PigmentCell&MelanomaResearch,28(2):161-170.
7.ZhichaoZhang,YuboLiu,TingSong,ZuguangXue,XiaoyunShen,FurongLiang,YanZhao,ZhiqiangLi,HongkunSheng.(2013)AnantiapoptoticBcl-2familyproteinindexpredictstheresponseofleukaemiccellstothepan-Bcl-2inhibitorS1.BritishJournalofcancer108,1870-1878.
8.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1innon-smallcelllungcancercellsthatphosphorylateBimthroughERK1/2andleadtoitsproteasomaldegradation.JournalofThoracicOncology,8,S1061.
9.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.JournalofThoracicOncology,2013,8,S767.
10.ZhichaoZhang,YanZhao,TingSong,YuboLiu,XiangqianLi,PengchenSu,ShenghuiXie.(2013)StudyofbindingthermodynamicsintheoptimizationofBH3mimetics.ChemicalBiology&DrugDesign,82,4,394-400.
11.TingSong,FurongLiang,ZhichaoZhang,YuboLiu,HongkunSheng,MingzhouXie.(2013)S1killsMCF-7/ADRcellsmorethanMCF-7cells:Aprotectivemechanismofendoplasmicreticulumstress.Biomedicine&Pharmacotherapy,67,451-556
12.TingSong,XilongChang,ZhichaoZhang,YuboLiu,XiaoyunShen.(2012)S1,aNovelPan-BH3Mimetic,InducesApoptosisinMcl-1-OverexpressingCellsThroughBak.JournalofPharmacologicalSciences119,330-340.
13.XingHuang,ChuangWang,SongLi,YuboLiu,ZhichaoZhang.(2014)HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.JournalofFluorescence.24(4),1313-1317.
14.YuboLiu,ZhichaoZhang.Ananti-apoptoticBcl-2familyproteinindexpredictstheresponseofleukemiccellstothepan-Bcl-2inhibitorS1.AACRAnnualMeeting2013.CancerResearch:2013,73,1710.
15.SongT,ChaiG,LiuY,etal.Bcl‐2phosphorylationconfersresistanceonchroniclymphocyticleukaemiacellstotheBH3mimeticsABT‐737,ABT‐263andABT‐199byimpedingdirectbinding[J].Britishjournalofpharmacology,2016,173(3):471-483.
16.Wang,A.,Song,T.,Wang,Z.,Liu,Y.,Fan,Y.,Zhang,Y.,&Zhang,Z.(2016).MechanismofMcl‐1ConformationalRegulationUponSmallMoleculeBindingRevealedbyMolecularDynamicSimulation.Chemicalbiology&drugdesign,87(4),551-561.
17.SongT,ChaiG,LiuY,etal.MechanismofsynergyofBH3mimeticsandpaclitaxelinchronicmyeloidleukemiacells:Mcl-1inhibition[J].EuropeanJournalofPharmaceuticalSciences,2015,70:64-71.
18.Huang,X.,Wang,C.,Li,S.,Liu,Y.,&Zhang,Z.(2014).HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.Journaloffluorescence,24(4),1313-1317.
19.李景煜，刘宇博，宋婷，沈晓云，张志超。（2012）BH3模拟物S1诱导人类白血病细胞株K562凋亡的作用机制。白血病·淋巴瘤2012年21卷第12期
20.邢欣荣，刘宇博，程智逵，伍会健（2008）组蛋白修饰酶对基因转录的调控.生理科学进展2008年第39卷第4期

[科研工作]
在研项目：
1.国家自然科学基金青年项目（主持人）：利用小分子p53-BH3功能模拟物研究Bcl-2-like/p53二聚体调控内源凋亡的分子机制，2016-2018
2.辽宁省博士启动基金（主持人），2016-2018
3.校际合作项目（主持人）：具有生物正交反应标记的糖基供体化学合成，2016-2017
发表论文：
1.LiuY,RenY,CaoY,etal.DiscoveryofaLowToxicityO-GlcNAcTransferase(OGT)InhibitorbyStructure-basedVirtualScreeningofNaturalProducts[J].ScientificReports,2017,7.
2.LiuY,HuangH,LiuM,etal.MicroRNA-24-1suppressesmousehepatomacellinvasionandmetastasisviadirectlytargetingO-GlcNActransferase[J].Biomedicine&Pharmacotherapy,2017,91:731-738.
3.LiuY,HuangH,CaoY,etal.SuppressionofOGTbymicroRNA24reducesFOXA1stabilityandpreventsbreastcancercellsinvasion[J].BiochemicalandBiophysicalResearchCommunications,2017,487(3):755-762.
4.YuboLiu,ZhichaoZhang,TingSong,FurongLiang,MingzhouXie,HongkunSheng.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.BritishJournalofPharmacology,169,1612-1623.
5.YuboLiu,ZhiqiangLi,TingSong,ZuguangXue,ZhichaoZhang.(2013)MechanismsofAnti-leukemicActivityoftheBcl-2HomologyDomain-3MimeticS1.Biomedicine&Pharmacotherapy,67,451-556.
6.YuboLiu，MingzhouXie，TingSong，HongkunSheng,XiaoyanYu,ZhichaoZhang.(2015)AnovelBH3mimeticefficientlyinducesapoptosisinmelanomacellsthroughdirectbindingtoanti-apoptoticBcl-2familyproteins，includingphosphorylatedMcl-1.PigmentCell&MelanomaResearch,28(2):161-170.
7.ZhichaoZhang,YuboLiu,TingSong,ZuguangXue,XiaoyunShen,FurongLiang,YanZhao,ZhiqiangLi,HongkunSheng.(2013)AnantiapoptoticBcl-2familyproteinindexpredictstheresponseofleukaemiccellstothepan-Bcl-2inhibitorS1.BritishJournalofcancer108,1870-1878.
8.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1innon-smallcelllungcancercellsthatphosphorylateBimthroughERK1/2andleadtoitsproteasomaldegradation.JournalofThoracicOncology,8,S1061.
9.YuboLiu,ZhichaoZhang.(2013)ResistancetoBH3mimeticS1inSCLCcellsthatup-regulateandphosphorylateBcl-2throughERK1/2.JournalofThoracicOncology,2013,8,S767.
10.ZhichaoZhang,YanZhao,TingSong,YuboLiu,XiangqianLi,PengchenSu,ShenghuiXie.(2013)StudyofbindingthermodynamicsintheoptimizationofBH3mimetics.ChemicalBiology&DrugDesign,82,4,394-400.
11.TingSong,FurongLiang,ZhichaoZhang,YuboLiu,HongkunSheng,MingzhouXie.(2013)S1killsMCF-7/ADRcellsmorethanMCF-7cells:Aprotectivemechanismofendoplasmicreticulumstress.Biomedicine&Pharmacotherapy,67,451-556
12.TingSong,XilongChang,ZhichaoZhang,YuboLiu,XiaoyunShen.(2012)S1,aNovelPan-BH3Mimetic,InducesApoptosisinMcl-1-OverexpressingCellsThroughBak.JournalofPharmacologicalSciences119,330-340.
13.XingHuang,ChuangWang,SongLi,YuboLiu,ZhichaoZhang.(2014)HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.JournalofFluorescence.24(4),1313-1317.
14.YuboLiu,ZhichaoZhang.Ananti-apoptoticBcl-2familyproteinindexpredictstheresponseofleukemiccellstothepan-Bcl-2inhibitorS1.AACRAnnualMeeting2013.CancerResearch:2013,73,1710.
15.SongT,ChaiG,LiuY,etal.Bcl‐2phosphorylationconfersresistanceonchroniclymphocyticleukaemiacellstotheBH3mimeticsABT‐737,ABT‐263andABT‐199byimpedingdirectbinding[J].Britishjournalofpharmacology,2016,173(3):471-483.
16.Wang,A.,Song,T.,Wang,Z.,Liu,Y.,Fan,Y.,Zhang,Y.,&Zhang,Z.(2016).MechanismofMcl‐1ConformationalRegulationUponSmallMoleculeBindingRevealedbyMolecularDynamicSimulation.Chemicalbiology&drugdesign,87(4),551-561.
17.SongT,ChaiG,LiuY,etal.MechanismofsynergyofBH3mimeticsandpaclitaxelinchronicmyeloidleukemiacells:Mcl-1inhibition[J].EuropeanJournalofPharmaceuticalSciences,2015,70:64-71.
18.Huang,X.,Wang,C.,Li,S.,Liu,Y.,&Zhang,Z.(2014).HighlySensitiveVisualizationofInorganicMercuryinMouseNeuronsUsingaFluorescentProbe.Journaloffluorescence,24(4),1313-1317.
19.李景煜，刘宇博，宋婷，沈晓云，张志超。（2012）BH3模拟物S1诱导人类白血病细胞株K562凋亡的作用机制。白血病·淋巴瘤2012年21卷第12期
20.邢欣荣，刘宇博，程智逵，伍会健（2008）组蛋白修饰酶对基因转录的调控.生理科学进展2008年第39卷第4期

[教育背景]
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