郑州大学化学与分子工程学院导师：于明明 正文

　
　　姓名：于明明　　性别：男　　职称：副教授　　
　　学院：化学与分子工程学院　最后学历：博士
　　电话：0371-67781205    电子邮件：
　　个人网址：
　　实验室：化学实验楼121 办公室：化学实验楼118
　　通讯地址：郑州大学化学系 450001

　　学历教育：
　　● 吉林大学学士（1994），吉林大学硕士（1998）
　　● 中科院理化所博士（2002）
　　● 清华大学博士后（2005）

　　研究兴趣：
　　生物荧光分子探针：过渡金属及重金属广泛地存在于自然界中，其中的一些元素在生命过程中具有非常重要的功能，如已知铜在肿瘤血管生长因子中扮演非常重要的调节作用,锌广泛参与细胞生长发育、基因转录、神经传递等各种重要生命过程；而另外一些元素则在很低浓度时就对生物具有极强的毒性,如铅能引起消化系统、神经系统及心脏的病变，汞对肾功能会引起严重损伤。因此，这些物质的检测对生命、环境和医学科学以及工农业生产等具有重要的意义。
　　课题研究具有高灵敏性、快速响应、高空间分辨率的荧光分子探针，探讨探针的识别机制，用无损伤细胞的方法测定细胞内游离金属的浓度，研究某种能够通透细胞膜的金属探针试剂，并在细胞内与金属离子发生作用等，可望用于细胞内的分子荧光成像。
　　功能高分子材料、荧光高分子：研究特殊结构高分子（超支化高分子、树枝状高分子、温敏高分子、pH敏感高分子）的荧光响应、能量传递、生物模拟以及高分子结构与荧光相互作用的规律。这方面研究期望用于人造太阳能光收集、荧光离子捕获、荧光染料以及生物标记与药物输运领域。

　　目前主持的研究课题：
　　● 国家自然科学基金“具有双识别协同作用的锌、铜离子荧光分子探针”（项目批准号：50903075）
　　● 中国科学院光化学转换与功能材料重点实验室开放课题“人造捕光天线的分子设计与应用”

　　近期代表文章：
　　1. Zhanxian Li, Lifeng Zhang, Lina Wang, Yongkai Guo, Lianheng Cai, Mingming Yu,* Liuhe Wei* Highly Sensitive and Selective Fluorescent Sensor for Zn2+/Cu2+ and New Approach for Sensing Cu2+ by Central Metal Displacement Chem. Comm., 2011, published online. (c1cc10696a) (Impact Factor: 5.504)
　　2. Zhanxian Li, Mingming Yu,* Lifeng Zhang, Ming Yu, Jinxia Liu, Liuhe Wei,* and Hongyan Zhang* A “switching on” fluorescent chemodosimeter of selectivity to Zn2+ and its application to MCF-7 cells Chem. Comm., 2010, 46, 7169 - 7171. (Impact Factor: 5.504)
　　3. Ming Ming Yu, Xia Li, Miao Luan, Jun Na Gao, Qiu Zhi Shi, Ming Sheng Tang, Liu He Wei An improved synthesis of bis(cyclopentadienone) Chin. Chem. Lett., 2010, 21, 1157-1161.
　　4. Ming-Ming Yu, Zhan-Xian Li, Liu-He Wei, Dong-Hui Wei, Ming-Sheng Tang A 1,8-Naphthyridine-based Fluorescent Chemodosimeter for the Rapid Detection of Zn2+ and Cu2+ Org. Lett., 2008, 22(10), 5115-5118. (Impact Factor: 5.420)
　　5. Ming-Ming Yu, Hui-Zhong Kou, Zhong-Hai Ni, Chong-Chao Zhao, Ai-Li Cui Synthesis and Study of Ferromagnetic μ1,1-Azido-Bridged Manganese(II) Dinuclear Complexes with S=5 and S = 5 × 2 2 Ground State Eur. J. Inorg. Chem., 2007, 5670-5676. (Impact Factor: 2.9)
　　6. Zhan-Xian Li, Wen-Fu Fu, Ming-Ming Yu, Xi-Juan Zhao, Yong Chen The synthesis and properties of phenolic schiff bases based on 1,8-naphthyridine Dyes and Pigments, 2007, 75, 516-520. (Impact Factor: 2.855)

　　专利：
　　于明明，李占先，魏英耐，魏柳荷，石秋芝“一种锌、铜离子荧光探针及其制备方法与应用”专利公开号：CN101446547
　　李占先，于明明，张利锋，虞明，魏柳荷，刘金霞“一种检测细胞内锌离子的分子荧光开关及其应用”专利公开号：CN101914375

　　Experience:
　　Department of Chemistry, Zhengzhou University, Zhengzhou, 2007-present
　　Department of Chemistry, Tsinghua University, Beijing, 2005-2007: Post Doctor
　　Technical Institute of Physics and Chemistry of CAS, Beijing, 2002-2005: Ph. D.
　　Jilin University, Changchun Jilin, 1998-2001: MS
　　Jilin University, Changchun Jilin, 1994-1998: BS
　　
　　Research Areas:
　　Fluorescent molecules
　　Functional polymers
　　Grant Support:
　　National Science Foundation of China, Synergy with Dual Recognition of Zinc, Copper Ion Fluorescence Molecular Probe (Grant no. 50903075), 2010-2013.
　　Open fundation of Key Laboratory of Photochemical Conversion and Optoelectronic Materials，TIPC，CAS
　　
　　Papers:
　　Huiqiang Li, Zhanxian Li, Linzhi Wu, Fang Liu, Jie Zhou, Miao Luan, Mingming Yu*, Liuhe Wei* Water-Soluble Starlike Poly(acrylic acid) Graft Polymer: Preparation and Application as Templates for Silver Nanoclusters polymer bulletin, accepted.
　　Zhanxian Li*, Lifeng Zhang, Xiaoya Li, Yongkai Guo, Zhonghai Ni, Jianhong Chen, Liuhe Wei, Mingming Yu* A fluorescent color/intensity changed chemosensor for Fe3+ by photo-induced electron transfer (PET) inhibition of fluoranthene derivative Dyes and Pigments, accepted.
　　Zhanxian Li, Wanying Zhao, Yuna Zhang, Lifeng Zhang, Mingming Yu*, Jinxia Liu* and Hongyan Zhang* An “off-on” fluorescent chemosensor of selectivity to Cr3+ and its application to MCF-7 cells Tetrahedron, 2011, 67, 7096 - 7100.
　　Zhan-Xian Li, Li-Feng Zhang, Wan-Ying Zhao, Xiao-Ya Li, Yong-Kai Guo, Ming-Ming Yu*, Jin-Xia Liu* Fluoranthene-based pyridine as fluorescent chemosensor for Fe3+ Inorg. Chem. Commun., 2011, 14, 1656 - 1658.
　　Zhanxian Li, Lifeng Zhang, Lina Wang, Yongkai Guo, Lianheng Cai, Mingming Yu,* Liuhe Wei* Highly Sensitive and Selective Fluorescent Sensor for Zn2+/Cu2+ and New Approach for Sensing Cu2+ by Central Metal Displacement Chem. Comm., 2011, 47, 5798 – 5800.
　　Zhanxian Li, Mingming Yu,* Lifeng Zhang, Ming Yu, Jinxia Liu, Liuhe Wei,* and Hongyan Zhang* A “switching on” fluorescent chemodosimeter of selectivity to Zn2+ and its application to MCF-7 cells Chem. Comm., 2010, 46, 7169 - 7171.
　　Ming Ming Yu, Xia Li, Miao Luan, Jun Na Gao, Qiu Zhi Shi, Ming Sheng Tang, Liu He Wei An improved synthesis of bis(cyclopentadienone) Chin. Chem. Lett., 2010, 21, 1157-1161.
　　Ming-Ming Yu, Zhan-Xian Li, Liu-He Wei, Dong-Hui Wei, Ming-Sheng Tang A 1,8-Naphthyridine-based Fluorescent Chemodosimeter for the Rapid Detection of Zn2+ and Cu2+ Org. Lett., 2008, 22(10), 5115-5118.
　　Ming-Ming Yu, Hui-Zhong Kou, Zhong-Hai Ni, Chong-Chao Zhao, Ai-Li Cui Synthesis and Study of Ferromagnetic μ1,1-Azido-Bridged Manganese(II) Dinuclear Complexes with S=5 and S = 5 × 2 Ground State Eur. J. Inorg. Chem., 2007, 5670-5676.
　　YU Ming-Ming, KOU Hui-Zhong, ZHAO Chong-Chao, ZHENG Lei, CUI Ai-Li Synthesis and crystal structure of two coordination compounds CuLClOH and Ni(L)2 [L = 2-carboxy-1,10-phenanthroline] Chinese J. of Struct. Chem., 2008, 27, 610-615.
　　YU Ming-Ming, ZHAO Xi-Juan, FU Wen-Fu Synthesis, Structure and Luminescent Properties of Polymeric Copper(I) Halide Complexes Bearing Phosphine and N-donor Bridging Ligands Chinese J. of Struct. Chem., 2007, 26, 1179-1183.
　　Zhan-Xian Li, Wen-Fu Fu , Ming-Ming Yu, Xi-Juan Zhao, Yong Chen The synthesis and properties of phenolic schiff bases based on 1,8-naphthyridine Dyes and Pigments, 2007, 75, 516–520.
　　Zhan Xian LI, Mei Gong FAN, Wen Fu FU, Ming Ming YU, Xi Juan ZHAO, De Hui WANG Synthesis of New O٨N٨C Ligands Chin. Chem. Lett., 2006, 17(8), 1017-1020.

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